Helminth infection induces a distinct subset of CD101hi lung tissue–infiltrating eosinophils that are differentially regulated by type 2 cytokines

• DOI: 10.1111/imcb.12796
• Publication Date: 2024-06-26T07:13:55Z
• Authors: Sophia‐Louise Noble; Francesco Vacca; Kerry L Hilligan; Thomas C Mules; Graham Le Gros; Stephen Inns
• Keywords: Nippostrongylus brasiliensis; Proinflammatory cytokine; Pulmonary Eosinophilia; Allergic Inflammation

Abstract Eosinophils play divergent roles in health and disease, contributing to both immunoregulatory proinflammatory responses. Helminth infection is strongly associated with eosinophilia the induction of type 2 cytokines interleukin (IL)‐5, IL‐4 IL‐13. This study aimed elucidate heterogeneity pulmonary eosinophils response helminth IL‐5, IL‐13 driving eosinophil Using murine model Nippostrongylus brasiliensis ( Nb ), we characterize a subtype eosinophils, defined by high expression CD101, that induced lungs ‐infected mice are phenotypically distinct from lung express low levels CD101. Strikingly, show two subtypes have anatomical localization within lung: CD101 predominantly localized vasculature, whereas ‐induced hi extravascular niche. We also across other models inflammation, including nonlung‐migrating infection, house dust mite–induced allergic inflammation influenza infection. Furthermore, demonstrate tissue independent IL‐5 signaling, but dependent on intact signaling. These results suggest produced during disease states promotes tissue‐infiltrating program