High incidence of aseptic hip necrosis in Hodgkin lymphoma patients treated with escalated BEACOPP receiving methylprednisolone

• DOI: 10.1111/imj.13653
• Publication Date: 2017-10-25T13:06:46Z
• Authors: Sandra Basic‐Kinda; Ivan Karlak; Nadira Durakovic; Zvonimir I. Lubina; Ivo Livaja Radman; Snježana Dotlic; Zinaida Peric; Ida Hude; Igor Aurer
• Keywords: Avascular Necrosis; Cumulative incidence; Regimen

Escalated BEACOPP (eBEACOPP) is an effective but fairly toxic regimen for the treatment of Hodgkin lymphoma (HL). Avascular necrosis (AVN) femoral head was previously reported to increase in patients treated with eBEACOPP, so far, no systematic analysis its frequency has been published.To analyse and identify possible risk factors AVN development eBEACOPP.We identified 26 eBEACOPP newly diagnosed high-risk advanced-stage HL, 25 whom were alive at time study. All invited participate a cross-sectional study; 17 responded evaluated by magnetic resonance imaging orthopaedic examination.Six (35.3%) after receiving treatment. not correlated age, gender, number received cycles, irradiation therapy or cumulative dose steroids administered. There significantly more cases methylprednisolone than prednisone (P = 0.01).The use shown be factor should corticosteroid choice HL.