Signal transducer and activator of transcription 3 (Stat3) contributes to T‐cell homeostasis by regulating pro‐survival Bcl‐2 family genes

• DOI: 10.1111/imm.12133
• Publication Date: 2013-06-08T09:36:49Z
• Authors: Jin‐Ku Lee; Cheolhee Won; Eun Hee Yi; Seung‐Hyeok Seok; Myoung‐Hwan Kim; Sang‐Jeong Kim; Myung‐Hee Chung; Hyun Gyu Lee; Koichi Ikuta; Sang‐Kyu Ye
• Keywords: Homeostasis

Summary The naive T ‐cell pool in peripheral lymphoid tissues is fairly stable terms of number, diversity and functional capabilities spite the absence prominent stimuli. This stability attributed to continuous tuning composition by various homeostatic signals. Despite extensive research into link between signal transducer activator transcription 3 ( S tat3) survival, little known about how tat3 regulates homeostasis maintaining required population organs. We assessed whether elimination cells limits survival. demonstrated that proportion number single‐positive thymocytes as well spleen lymph nodes were significantly decreased tat3‐deficient group a result enhanced susceptibility tat3‐deleted lymphocytes apoptosis. Importantly, expression anti‐apoptotic Bcl‐2 Bcl‐xL was markedly lymphocytes, suggesting helps maintain resting condition promoting family genes. These findings suggest importance integration cues for maintenance pool.