Heme oxygenase‐1 inhibits basophil maturation and activation but promotes its apoptosis in T helper type 2‐mediated allergic airway inflammation

• DOI: 10.1111/imm.12564
• Publication Date: 2015-12-14T09:54:52Z
• Authors: Wenwei Zhong; Caixia Di; Jiajia Lv; Yanjie Zhang; Xiaoliang Lin; Yufan Yuan; Jie Lv; Zhenwei Xia
• Keywords: Basophil activation; Allergic Inflammation

The anti-inflammatory role of heme oxygenase-1 (HO-1) has been studied extensively in many disease models including asthma. Many cell types are targets HO-1, such as dendritic cells and regulatory T cells. In contrast to previous reports that HO-1 had limited effects on basophils, which participate helper type 2 immune responses antigen-induced allergic airway inflammation, we demonstrated this study, for the first time, up-regulation significantly suppressed maturation mouse decreased expression CD40, CD80, MHC-II activation marker CD200R blocked DQ-ovalbumin uptake promoted basophil apoptosis both vitro vivo, leading inhibition polarization. These were mimicked by exogenous carbon monoxide, is one catalytic products HO-1. Furthermore, adoptive transfer HO-1-modified basophils reduced ovalbumin-induced inflammation. above can be reversed inhibitor Sn-protoporphyrin IX. Moreover, conditional depletion accompanying hemin treatment further attenuated inflammation compared with group, indicating protective may involve multiple Collectively, our findings exerted its function through suppression activation, but promotion apoptosis, providing a possible novel therapeutic target