Expression of melatonin receptors and CD4 in the ovine thymus, lymph node, spleen and liver during early pregnancy
0301 basic medicine
Sheep
Gene Expression Profiling
Receptors, Melatonin
Thymus Gland
Real-Time Polymerase Chain Reaction
Histocompatibility, Maternal-Fetal
Up-Regulation
3. Good health
03 medical and health sciences
Liver
Pregnancy
CD4 Antigens
Immune Tolerance
Animals
Pregnancy, Animal
Female
Lymph Nodes
Spleen
Melatonin
Signal Transduction
DOI:
10.1111/imm.13180
Publication Date:
2020-02-13T11:41:01Z
AUTHORS (6)
ABSTRACT
Summary As a pineal gland hormone, melatonin acts through its receptors to modulate the immune system. The system is composed of primary and secondary organs, organs are adapted presence fetal alloantigen during pregnancy. However, it unclear whether affects maternal early pregnancy in sheep. In this study, ovine thymus, lymph node, spleen liver were sampled at day 16 oestrous cycle, days 13, 25 expression receptor 1A (MT1), 1B (MT2) cluster differentiation 4 (CD4) was detected by quantitative real‐time polymerase chain reaction, Western blot immunohistochemistry experiments. Our results showed that there an upregulation MT1 mRNA protein node liver, downregulation spleen. MT2 increased thymus but decreased no significant change CD4 upregulated changes conclusion, induces tissue‐specific MT1, CD4, which may be due different functions liver. Further, involved regulation
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