CD5L is upregulated upon infection with Mycobacterium tuberculosis with no effect on disease progression

• DOI: 10.1111/imm.13825
• Publication Date: 2024-06-24T01:28:23Z
• Authors: Marcos S. Cardoso; Rute Gonçalves; Liliana Oliveira; Diogo Silvério; Érica Téllez; Tony Paul; Maria Rosa Sarrias; Alexandre M. Carmo; Margarida Saraiva
• Keywords: CD4-Positive T-Lymphocytes; Mice, Knockout; Scavenger Receptors, Class A; Mycobacterium tuberculosis; Up-Regulation; Mice, Inbred C57BL; Mice; Disease Models, Animal; Interferon-gamma; Disease Progression; Animals; Tuberculosis; Female; Lung; Tuberculosis, Pulmonary; Biomarkers

Abstract Tuberculosis (TB) alone caused over a billion deaths in the last 200 years, making it one of deadliest diseases to humankind. Understanding immune mechanisms underlying protection or pathology TB is key uncover much needed innovative approaches tackle TB. The scavenger receptor cysteine‐rich molecule CD5 antigen‐like (CD5L) has been associated with TB, but whether and how CD5L shapes response during course disease remains poorly understood. Here, we show an upregulation circulation at site infection C57BL/6 Mycobacterium tuberculosis ‐infected mice. To investigate role studied progression M. aerosol recently described genetically engineered mouse model lacking CD5L. Despite increase wild‐type mice, absence did not impact bacterial burden, histopathology survival infected Absence modest numbers CD4+ T cells expression IFN‐γ lungs no major effect overall cell dynamics. Collectively, this study confirms as potential diagnostic biomarker showing discernible on outcome infection.