Prevalence and Risk Factors of Chemotherapy‐Induced Oral Mucositis in 470 Children With Acute Lymphoblastic Leukemia

• DOI: 10.1111/ipd.13303
• Publication Date: 2025-03-12T00:54:55Z
• Authors: Xiaofeng He; Xinwen Rong; Weijie Wang; Lichan Liang; Xiaomei Liao; Jiaying Huang; Jing Zhang; Wenting Zhu; Weifei Liu; Lei Shi
• Keywords: Mucositis; Acute lymphocytic leukemia; Univariate analysis

To assess the prevalence and risk factors of chemotherapy-induced oral mucositis in 470 children with acute lymphoblastic leukemia China, focusing on treatment-related factors. This cross-sectional study included diagnosed China from January 2020 to July 2022. Data were collected electronic medical records, field investigations, telephone follow-ups, covering sociodemographic characteristics, nutritional status, disease treatment history, microbiological Univariate multivariate logistic analyses used evaluate association between occurrence severity these variables. The was 45.1%. Significant receiving more than five chemotherapy cycles (p < 0.001), carrying HSV-1 = 0.016), infection Candida albicans 0.012), undergoing specific drugs containing methotrexate/daunorubicin/cytarabine having a high clinical stratification 0.002), being over 6 years old 0.002). associated consolidation intensification period 0.001) B-cell immune 0.001). is relatively high. It emphasizes importance staff paying attention this issue adopting targeted interventions reduce patient population.