Establishment of a novel rat model for deep tissue injury deterioration

• DOI: 10.1111/iwj.12082
• Publication Date: 2013-05-08T05:05:27Z
• Authors: Yunita Sari; Takeo Minematsu; Lijuan Huang; Hiroshi Noguchi; Taketoshi Mori; Gojiro Nakagami; Takashi Nagase; Makoto Oe; Junko Sugama; Kotaro Yoshimura; Hiromi Sanada
• Keywords: Haematoxylin

Abstract Deep tissue injuries ( DTI s) can become significant problems because of their rapid deterioration into deep pressure ulcers. Presently, no animal model has been developed. By concentrating and shear stress in tissues while minimising the overlying skin, we produced an effective rat deterioration. Two‐dimensional finite element method FEM ) simulated distribution under several pressure‐loading conditions. showed that concentrated with minimum skin could be created by using a prominence cushion, respectively. On basis results analysis, selected suitable conditions for testing model. The compressed area was macroscopically observed until day 13, histopathologic analysis via haematoxylin eosin H&E staining performed on days 3, 7 13. damage similar to predicted results. ulceration extending from surrounding were model, which are clinical manifestations In conclusion, representative established high skin. This will allow better understanding mechanisms behind development preventative strategies.