Role of verapamil in preventing and treating hypertrophic scars and keloids

• DOI: 10.1111/iwj.12455
• Publication Date: 2015-05-13T02:34:54Z
• Authors: Ru Wang; Yu Mao; Zhenyu Zhang; Zhengyong Li; Junjie Chen; Ying Cen
• Keywords: Keloid; Hypertrophic scars; Hypertrophic scars

Abstract Keloid and hypertrophic scars are difficult to manage remain a therapeutic challenge. Verapamil has shown great potential in the management of keloid scars. Comparing with conventional corticosteroid injections, verapamil could improve appearance scars, is associated lower incidence adverse effects. Is an effective alternative modality prevention treatment scars? The aim this study was assess effectiveness preventing treating Searches were conducted Medline, EMbase Cochrane databases from 1974 January 2015. selection articles limited human subjects. Five randomised controlled trials ( RCTs ) or cluster‐randomised clinical CCTs comparing efficacy treatments identified. results showed that not significantly different injections. Few effects observed. However, result should be considered carefully, as most included studies have high risk bias because issues randomization, allocation concealment, blinding, incomplete outcomes selective reporting. In conclusion, act More high‐quality, multiple‐centre, large‐sample required define role