Antibacterial Activity of Hydrolyzable Tannins Derived from Medicinal Plants against Helicobacter pylori

• DOI: 10.1111/j.1348-0421.2004.tb03521.x
• Publication Date: 2013-11-14T15:13:20Z
• Authors: Keiji Funatogawa; Shunji Hayashi; Hirofumi Shimomura; Takashi Yoshida; Tsutomu Hatano; Hideyuki Ito; Yoshikazu Hirai
• Keywords: Flavonoids; 0301 basic medicine; Plants, Medicinal; Helicobacter pylori; Terpenes; Hydrolysis; Cell Membrane; Polyphenols; Microbial Sensitivity Tests; 15. Life on land; Hydrolyzable Tannins; Anti-Bacterial Agents; 3. Good health; 03 medical and health sciences; Glucosides; Phenols; Gallic Acid; Tumor Cells, Cultured; Humans; Acids; Tannins

AbstractHelicobacter pylori is a major etiological agent in gastroduodenal disorders. In this study, we isolated 36 polyphenols and 4 terpenoids from medicinal plants, and investigated their antibacterial activity against H. pylori in vitro. All hydrolyzable tannins tested demonstrated promising antibacterial activity against H. pylori. Monomeric hydrolyzable tannins revealed especially strong activity. Other compounds demonstrated minimal antibacterial activity with a few exceptions. A monomeric hydrolyzable tannin, Tellimagrandin I demonstrated time‐ and dose‐dependent bactericidal activity against H. pylori in vitro. On the other hand, hydrolyzable tannins did not affect the viability of MKN‐28 cells derived from human gastric epithelium. Hydrolyzable tannins, therefore, have potential as new and safe therapeutic regimens against H. pylori infection. Furthermore, we investigated effects of hydrolyzable tannins on lipid bilayer membranes. All the hydrolyzable tannins tested demonstrated dose‐dependent membrane‐damaging activity. However, it remains to be elucidated whether their membrane‐damaging activity directly contributes to their antibacterial action.