Induction of Intestinal Tumors and Lymphomas in C57BL/6N Mice by a Food‐borne Carcinogen, 2‐Amino‐l‐methyl‐6‐phenylimidazo[4,5‐b]pyridine

• DOI: 10.1111/j.1349-7006.2002.tb01281.x
• Publication Date: 2005-08-30T09:31:30Z
• Authors: Masako Ochiai; Hiroshi Imai; Takashi Sugimura; Minako Nagao; Hitoshi Nakagama
• Keywords: Heterocyclic amine; Ratón; Anticarcinogen

2‐Amino‐l‐methyl‐6‐phenylimidazo[4,5‐ b ]pyridine (PhIP) is the most abundant heterocyclic amine contained in cooked meat and fish. Although PhIP has been demonstrated to induce various types of tumors rats, lymphomas predominated mice using CDF1 strain. To investigate carcinogenic activity on other organs with a different genetic background, was administered C57BL/6N mice. After 40‐week administration 300 ppm high‐fat diet followed by continuous feeding high fat diet, developed adenomas adenocarcinomas small intestine, incidences being 52% males 68% females at weeks 95 70, respectively. Lymphomas B‐cell origin also both sexes as frequently strain, 48% 32% females. incidence PhIP‐treated female did not differ from that control mice, significantly earlier The present study intestinal tract another potential target PhIP‐induced carcinogenesis could be affected background animals.