Short‐chain fatty acid topical treatment in distal ulcerative colitis

• DOI: 10.1111/j.1365-2036.1995.tb00386.x
• Publication Date: 2010-07-23T12:05:47Z
• Authors: P. VERNIA; A. MARCHEGGIANO; R. CAPRILLI; G. FRIERI; G. CORRAO; D. VALPIANI; M. C. DI PAOLO; P. PAOLUZI; A. TORSOLI
• Keywords: Sodium propionate; Enema; Short-chain fatty acid

Some evidence indicates that short-chain fatty acid (SCFA) enemas are effective in the treatment of distal ulcerative colitis.In a randomized, double-blind, placebo-controlled study, we tested efficacy 6-week course topical SCFA (100 mL, twice daily sodium acetate 80 mmol/L, propionate 30 mmol/L and butyrate 40 mmol/L) patients with mild to moderate colitis. Clinical, endoscopic histological data were collected at beginning end study.Fourteen on improved (overall score 11.3 +/- 2.0 vs. 7.4 3.5) as compared five placebo group 10.0 1.9 8.9 2.5). In SCFA-treated all parameters significantly except number bowel motions, whereas no significant changes recorded control group. A statistically difference between two regimens, however, was observed only for intestinal bleeding (P < 0.05), urgency 0.02) patient self-evaluation 0.05). This probably due random inclusion more disease into group, thus causing pretrial differences groups.The present study confirms irrigation is colitis, may represent an alternative therapeutic tool disease.