Behaviour of the bowel wall during the first year after surgery is a strong predictor of symptomatic recurrence of Crohn's disease: a prospective study

• DOI: 10.1111/j.1365-2036.2004.02245.x
• Publication Date: 2004-11-02T09:26:00Z
• Authors: F. Parente; G. M. Sampietro; M. Molteni; S. Greco; A. Anderloni; C. Sposito; P. G. Danelli; A. M. Taschieri; S. Gallus; G. Bianchi Porro
• Keywords: Adult; Male; Adolescent; Middle Aged; Disease-Free Survival; 3. Good health; Colonic Diseases; 03 medical and health sciences; Postoperative Complications; Treatment Outcome; 0302 clinical medicine; Crohn Disease; ROC Curve; Recurrence; Risk Factors; Multivariate Analysis; Humans; Female; Prospective Studies; Ultrasonography

Recurrences after surgery for Crohn's disease are frequent and unpredictable. To date, there is little agreement as to which factors increase a patient risk of early recurrence.To assess whether the post-operative behaviour diseased bowel walls, determined by ultrasound, may be useful predictor relapse.A total 127 patients were monitored means ultrasound well clinical laboratory evaluations median follow-up 41.0 months. Bowel wall thickness loops measured at during was compared with presurgery values. Multivariable survival analysis performed elucidate predictors recurrence. Receiver operating characteristic curves also constructed taking into account selecting high clinical/surgical recurrence.The estimated 5 years probability symptomatic recurrence 90% 33%, respectively unchanged/worsened vs. improved 12 months from surgery. The hazard ratio 8.9 (95% CI: 3.4-23.2). curve identified > 6.0 mm directly associated having (hazard 6.5, 95% 2.8-15.4).Systematic walls conservative allows identification