Lactobacillus reuteri therapy to reduce side‐effects during anti‐Helicobacter pylori treatment in children: a randomized placebo controlled trial

• DOI: 10.1111/j.1365-2036.2006.03145.x
• Publication Date: 2006-10-10T08:06:13Z
• Authors: E. LIONETTI; V. L. MINIELLO; S. P. CASTELLANETA; A. M. MAGISTÁ; A. DE CANIO; G. MAUROGIOVANNI; E. IERARDI; L. CAVALLO; R. FRANCAVILLA
• Keywords: Lactobacillus reuteri; Urea breath test; Tinidazole; Regimen

Summary Background Helicobacter pylori eradication fails in about 25–30% of children, particularly because the occurrence resistance to antibiotics and side‐effects. Aim To determine whether adding Lactobacillus reuteri an anti‐ H. regimen could help prevent or minimize gastrointestinal side‐effects burden children. Methods Forty ‐positive children (21 males; median age: 12.3 years) were consecutively treated with 10‐day sequential therapy [omeprazole + amoxycillin for 5 days, omeprazole clarithromycin tinidazole other days] blindly randomized receive either L. ATCC 55730 (10 8 CFU) placebo. All completed Gastrointestinal Symptom Rating Scale (GSRS) at entry, during after treatment. status was assessed weeks by 13 C‐urea breath test. Results Overall, all probiotic supplemented when compared those receiving placebo there a significant reduction GSRS score (4.1 ± 2 vs. 6.2 3; P < 0.01) end follow‐up (3.2 5.8 3.4; 0.009). report less symptoms than Conclusion is capable reducing frequency intensity antibiotic‐associated .