Pharmacokinetics of the H2‐ receptor antagonist ranitidine in man.

• DOI: 10.1111/j.1365-2125.1981.tb01236.x
• Publication Date: 2012-07-26T16:33:21Z
• Authors: JJ McNeil; GW Mihaly; A Anderson; AW Marshall; RA Smallwood; WJ Louis
• Keywords: Half-life; Plasma clearance

1 Ranitidine pharmacokinetics were studied in six healthy volunteers. Following an overnight fast, doses of 20 mg intravenously 20, 40 and 100 orally with a standard meal, administered to each subject on separate occasions. 2 intravenous administration there was bioexponential decline plasma levels from 576 +/- 56 ng/ml at 4 min 10 8 h. The distribution half-life (T 1/2 alpha) 6.1 0.9 min, elimination beta) 1.9 0.1 h, the volume (Vd 115 7 l systemic clearance (Cltp) 709 62 ml/min. 3 oral doses, peak reached 1.6 0.2 h availability 88 10%. Elimination unaffected by dose area under curve increased linearly food. Renal excretion (24 h) unmetabolized ranitidine accounted for 50-70% further 1-3% appearing as desmethyl ranitidine.