The effects of sulindac and indomethacin on the anti‐hypertensive and diuretic action of hydrochlorothiazide in patients with mild to moderate essential hypertension.

• DOI: 10.1111/j.1365-2125.1986.tb05216.x
• Publication Date: 2012-07-26T22:19:21Z
• Authors: PP Koopmans; T. Thien; CM Thomas; RJ Van den Berg; FW Gribnau
• Keywords: Sulindac; Plasma renin activity; Essential hypertension

In this double‐blind two period crossover study, we investigated the effect of indomethacin and sulindac on blood pressure in 25 hypertensive patients being treated with hydrochlorothiazide. The study consisted seven 4 week periods. first last took placebos, two, four six they were hydrochlorothiazide 50 mg once daily alone, third fifth was given combination either twice or 200 random order. Blood pressure, measured by sphygmomanometer arteriosonde, body weight determined every 2 weeks. Compared placebo decreased mean arterial 8%. Addition both resulted only slight generally similar changes lowering effect. This found for whole group when treatment sequence groups analysed separately. contrast to sulindac, attenuated hydrochlorothiazide‐ induced decreases weight, plasma potassium increase renin activity. Both non‐steroidal anti‐inflammatory drugs (NSAID) reduced 24 h urinary excretion prostaglandins (PGs), i.e. PGF2 alpha, 6 ketoPGF1 alpha thromboxane B2 except PGE2. From it can be concluded that, diuretic action hydrochlorothiazide, however apparently without consequences its long‐term does not support hypothesis that difference between NSAIDs explained different effects renal PG synthesis.