Effects of grapefruit juice on the pharmacokinetics of pitavastatin and atorvastatin

• DOI: 10.1111/j.1365-2125.2005.02462.x
• Publication Date: 2005-10-19T09:23:14Z
• Authors: Hitoshi Ando; Shuichi Tsuruoka; Hayato Yanagihara; Koh‐ichi Sugimoto; Masaaki Miyata; Yasushi Yamazoe; Toshinari Takamura; Shuichi Kaneko; Akio Fujimura
• Keywords: Pitavastatin; Grapefruit juice; Crossover study; Citrus paradisi

Aims To compare the effects of grapefruit juice (GFJ) on pharmacokinetics pitavastatin and atorvastatin. Methods In a randomized, four‐phase crossover study, eight healthy subjects consumed either GFJ or water t.i.d. for 4 days in each trial. On final day, single dose mg 20 atorvastatin was administered. Results increased mean AUC 0−24 acid by 83% (95% CI 23–144%) that 13% (−3 to 29%). Conclusions Pitavastatin, unlike atorvastatin, appears be scarcely affected CYP3A4‐mediated metabolism.