Cellular adhesion molecules in chronic urticaria: modulation of serum levels occurs during levocetirizine treatment

• DOI: 10.1111/j.1365-2133.2006.07548.x
• Publication Date: 2006-10-19T10:04:30Z
• Authors: M. Caproni; W. Volpi; B. Giomi; D. Torchia; E. Del Bianco; P. Fabbri
• Keywords: Levocetirizine; Extravasation; E-selectin

Some antihistamines are capable of reducing levels adhesion molecules in wealing tissues patients with chronic urticaria (CU).To determine if 6 weeks therapy levocetirizine 5 mg once daily would also induce any decrease serum intercellular molecule-1, vascular cell endothelial leucocyte molecule-1 (ELAM-1) or P-selectin subjects CU and autoimmune urticaria.Thirty-six (18 positive 18 negative autologous skin test) were studied, together 10 control healthy subjects. All received daily. Serum soluble cellular molecule (CAM) determined by immunoenzymatic assay before after the end study period. Disease activity was recorded according to EAACI/GA(2)LEN/EDF scoring system.After CAM decreased CU, significantly cases ELAM-1 P-selectin. Patients' clinical scores improved during regular antihistamine therapy.Levocetirizine demonstrated a broad anti-inflammatory effect CU. The significant might reflect inhibitory on neutrophil rolling extravasation towards inflamed skin.