Expression of tachykinins and their receptors in plaque psoriasis with pruritus

• DOI: 10.1111/j.1365-2133.2011.10241.x
• Publication Date: 2011-02-07T14:26:23Z
• Authors: B. Amatya; H. El-Nour; M. Holst; E. Theodorsson; K. Nordlind
• Keywords: Tachykinin receptor 1; Skin biopsy

BACKGROUND Various mediators of pruritus have been suggested that might be responsible for the mechanism in psoriasis.To study expression levels members tachykinin family, substance P and neurokinin (NK) A their receptors, NK-1 NK-2, psoriasis to correlate with intensity pruritus. possible correlation chronic stress depression was also evaluated.Biopsies were obtained from 28 patients plaque psoriasis; majority had The samples taken lesional nonlesional areas on back 10 healthy controls, immunohistochemistry staining, skin radioimmunoassay. Prior biopsy, clinical severity each patient assessed by Psoriasis Area Severity Index (PASI) measured using a visual analogue scale (VAS). Levels Beck's Depression Inventory (BDI) salivary cortisol test, respectively.Substance P-, NKA- NK-2 receptor-immunoreactive nerves, non-neuronal inflammatory cells positive NKA respective numerous compared controls. numbers P-positive nerves receptor-positive significantly correlated intensity. ratio inversely number skin. There between BDI score skin.Tachykinins may play role per se, addition this disease. Targeting combined receptors treatment.