Multivariate analysis of factors associated with early-onset segmental and nonsegmental vitiligo: a prospective observational study of 213 patients

• DOI: 10.1111/j.1365-2133.2011.10311.x
• Publication Date: 2011-03-17T06:17:30Z
• Authors: K. Ezzedine; A. Diallo; C. Léauté-Labrèze; D. Mossalayi; Y. Gauthier; S. Bouchtnei; M. Cario-André; J. Seneschal; F. Boralevi; T. Jouary; A. Taieb
• Keywords: Vitiligo

Although mixed forms have been described recently, segmental (SV) and nonsegmental vitiligo (NSV) are considered as clinically distinct. However, limited epidemiological data available to help distinguish associated factors, recent genome-wide association studies restricted NSV. The higher prevalence of SV in children is helpful when comparing the two major presentations disease.To compare factors with NSV, especially for markers autoimmunity or autoinflammation.We conducted a single-centre prospective observational study patients aged 17 years under confirmed diagnosis NSV at clinic between 1 January 2006 July 2010. Vitiligo European Task Force questionnaire was completed each patient, thyroid function antithyroid antibodies were screened if not obtained previous year. Other (focal, mucosal, classifiable) excluded.A total 213 included, 142 59 12 vitiligo. There no significant statistical difference sex age onset Halo naevi significantly more frequent than [odds ratio (OR) 7·58, P < 0·01). Patients frequently had positive family history (OR 2·25, P=0·02) marked familial background 2·22, = 0·01).Our clearly shows that features inflammation (pruritus)/autoimmunity (halo naevi, antibodies) strongly linked together autoimmunity.