The Irreversibly Sickled Cell; a Determinant of Haemolysis in Sickle Cell Anaemia

• DOI: 10.1111/j.1365-2141.1969.tb01403.x
• Publication Date: 2008-03-12T13:53:27Z
• Authors: G. R. Serjeant; B. E. Serjeant; P. F. Milner
• Keywords: Haemolysis; Red Cell

S ummary . Red cell survival was estimated in a group of adult sickle anaemia patients using the 51 Cr technique. Counts irreversibly sickled cells were performed on thin coverslip preparations capillary blood. These counts are relatively constant within same individual but show marked variations between individuals. A significant correlation has been demonstrated count and red survival. This does not apply to with splenomegaly whom is always low.