Heterogeneity of FeNO response to inhaled steroid in asthmatic children

• DOI: 10.1111/j.1365-2222.2003.01822.x
• Publication Date: 2003-12-09T15:17:50Z
• Authors: F. Buchvald; H. Eiberg; H. Bisgaard
• Keywords: Exhalation

Summary Background Nitric oxide in exhaled air is regarded as an inflammation marker, and may be used to monitor the anti‐inflammatory control from inhaled corticosteroids (ICSs). However, this response ICSs exhibits a heterogeneous pattern. Objective The study aimed describe independent variables associated with heterogeneity of nitric ICSs. Methods Exhaled (FeNO), lung function, bronchial hyper‐responsiveness (BHR), specific IgE common inhalant allergens, blood eosinophils, other atopic manifestations variants synthethase 1 (NOS1) gene were studied double‐blind, placebo‐controlled crossover comparison budesonide (BUD) Turbohaler 1600 mcg daily vs. placebo asthmatic schoolchildren. Results Forty children included screening 184 moderately persistent asthma, well controlled on regular BUD 400 daily: 20 normal FeNO raised FeNO. FeNO, BHR forced expiratory volume s improved significantly after (BUD1600). ICS treatment exhibited Gaussian distribution was 15 children. Allergy BHR, but none under related BUD1600. Conclusion driving level independently high‐dose steroid treatment. This should considered when using for dose titration monitoring