Airway inflammation in nasal polyposis: immunopathological aspects of relation to asthma

• DOI: 10.1111/j.1365-2222.2005.02194.x
• Publication Date: 2005-03-21T22:25:09Z
• Authors: D. Ediger; B. A. Sin; A. Heper; Y. Anadolu; Z. Mιsιrlιgil
• Keywords: Nasal Polyps; Respiratory Hypersensitivity

Summary Background Nasal polyposis (NP) is a chronic inflammatory disorder of the upper respiratory tract, which often coexist with asthma. However, pathogenesis especially in patients NP still matter debate. Objective To better understand immunopathologic mechanism involved this relationship, we investigated cell profiles bronchial and nasal tissues alone concomitant Methods Seventeen (six male, 11 female, age range: 19–63, mean age: 38.29±13.27 years) were selected for study. Subjects divided into two groups based on presence asthma or hyper‐responsiveness (BHR). without BHR (Group 1) ( n =8), 2) =9). All underwent atopy evaluation including detailed history, skin prick test (SPT), total specific IgE determination sera. None subjects had taken inhaled, oral corticosteroids at least 1 month before Respiratory symptoms asthmatic controlled only short acting β 2 ‐agonist inhaler drugs as needed. tissue, mucosa biopsies from all using fiberoptic endoscopy. CD3, CD8, CD16, CD68, AA1 (mast tryptase), human leucocyte antigen‐DR (HLA‐DR) eosinophil peroxidase (EPO) expressing cells specimens determined by immunohistochemical methods. Positively staining types counted. Subepithelial lamina propria periglandular areas separately evaluated. Results No significant difference was found polyp CD3 + , CD8 CD16 CD68 HLA‐DR EPO positive between groups. There significantly higher numbers tissue vs. P <0.05). increased when compared both counts tended to be within isolated Also, showed more than those Immunoreactivity eosinophils prominent alone. The number negative (SPT −ve) group SPT +ve) ones. Conclusions Our results demonstrate that infiltration lower airways do not remarkably differ who has no evidence NP. SPT−ve reveal intense eosinophilic inflammation entire mucosa.