Effects of tacrolimus ointment on Toll-like receptors in atopic dermatitis

• DOI: 10.1111/j.1365-2230.2010.03948.x
• Publication Date: 2010-11-10T12:31:18Z
• Authors: E. Antiga; W. Volpi; D. Torchia; P. Fabbri; M. Caproni
• Keywords: Atopy

Background. Alterations of Toll‐like receptors (TLRs) seem to play a role in susceptibility atopic dermatitis (AD). Aim. To investigate the expression TLRs moderate severe chronic AD adults before and after 3‐week treatment with 0.1% tacrolimus ointment, compared topical hydrocortisone‐17‐butyrate. Methods. In total, 21 adult patients were enrolled: 11 given ointment 10 hydrocortisone butyrate; further 6 healthy formed control group. The clinical efficacy was assessed using SCORing Atopic Dermatis (SCORAD) index. Biopsies taken from lesional skin treatment, which stained immunohistochemically monoclonal antibodies TLR‐1, ‐2, ‐4 ‐9. Results. Both treatments improved signs symptoms all considered, no significant difference between two groups. AD, TLR‐1 overexpressed TLR‐2 underexpressed controls, whereas differences found for TLR‐4 TLR‐9. Staining decreased both groups treatment. specimens had higher levels either baseline, than butyrate. Neither nor butyrate affected or Conclusion. Short‐term therapy reduced may inhibit antimicrobial potential TLR‐2, also reversed impairment lesions. Expression TLR‐9 not by tacrolimus.