Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms in gastric cancer of intestinal and diffuse histotypes

• DOI: 10.1111/j.1365-2249.2008.03776.x
• Publication Date: 2008-11-05T12:38:12Z
• Authors: D Santini; S Angeletti; A Ruzzo; G Dicuonzo; S Galluzzo; B Vincenzi; A Calvieri; F Pizzagalli; N Graziano; E Ferraro; G Lorino; A Altomare; M Magnani; F Graziano; G Tonini
• Keywords: Adult; Aged, 80 and over; Male; 0303 health sciences; Polymorphism, Genetic; Adenocarcinoma; Middle Aged; 3. Good health; Toll-Like Receptor 4; 03 medical and health sciences; Risk Factors; Stomach Neoplasms; Case-Control Studies; Humans; Female; Genetic Predisposition to Disease; Aged

Summary In the present study we investigated potential role of Toll-like receptor 4 (TLR-4) Asp299Gly and Thr399Ile polymorphisms as risk factors in development gastric cancer. TLR-4 were 171 Italian patients with sporadic cancer 151 controls. Unconditional regression (odds ratio 95% confidence intervals) used to investigate association studied polymorphism is linked an increased susceptibility (P = 0·023 hazard 3·62). No significant for was found. subgroup intestinal-type cancer, a associated genotype 0·006). Our results demonstrated that An intestinal carriers TLR4 allele observed. Future epidemiological studies should consider possible interactions between proinflammatory genotypes (such TLR interleukin-1R polymorphisms) other such dietary habits and/or exposure environmental carcinogens.