Carcinoma ex pleomorphic adenoma with special reference to the prognostic significance of histological progression: a clinicopathological investigation of 41 cases

• DOI: 10.1111/j.1365-2559.2011.03937.x
• Publication Date: 2011-10-21T11:53:45Z
• Authors: Christoph Weiler; Pamela Zengel; Jacqueline E van ...; Orlando Guntinas-...; Stephan Schwarz; John D Harrison; Thomas Kirchner; Stephan Ihrler
• Keywords: pleomorphic adenoma; Adult; Male; recurrence; SALIVARY-GLANDS; Adenoma, Pleomorphic; Kaplan-Meier Estimate; 03 medical and health sciences; 0302 clinical medicine; Humans; MALIGNANT MIXED TUMORS; intraductal carcinoma; Aged; Aged, 80 and over; carcinoma ex pleomorphic adenoma; PAROTID-GLAND; Carcinoma; Middle Aged; Prognosis; Salivary Gland Neoplasms; Immunohistochemistry; 3. Good health; salivary gland disease; Cell Transformation, Neoplastic; Disease Progression; salivary gland carcinoma; Female; prognosis

Weiler C, Zengel P, van der Wal J E, Guntinas-Lichius O, Schwarz S, Harrison D, Kirchner T & Ihrler S(2011) Histopathology59, 741–750 Carcinoma ex pleomorphic adenoma with special reference to the prognostic significance of histological progression: a clinicopathological investigation 41 cases Aims: To investigate large series carcinoma (CEPA) determine factors. Methods and results: Thirty CEPA associated primary (PA) 11 recurrent PA were investigated. The median follow-up was 57.7 months, ranged from 4 156 months. Purely intraductal found in 15 cases. Intraductal extraductal intracapsular together one case. Extracapsular 25 Prognosis good for that purely intraductal, intracapsular, or up 5 mm extracapsular, poor 8 more extracapsular. There relatively extracapsular invasion than PA, prognosis worse PA. Conclusions: threshold distinguishing minor wide is mm. indicates necessity close surveillance patients