Characterization of spore forming Bacilli isolated from the human gastrointestinal tract

• DOI: 10.1111/j.1365-2672.2008.03934.x
• Publication Date: 2008-10-17T10:51:10Z
• Authors: S. Fakhry; I. Sorrentini; E. Ricca; M. De Felice; L. Baccigalupi
• Keywords: Human gastrointestinal tract; Human pathogen

To isolate and characterize spore-former bacteria able to colonize the human gastrointestinal tract (GIT).A total of 25 spore-formers was isolated from faeces ileal biopsies healthy volunteers identified at species level. Physiological analysis performed evaluate ability various isolates form biofilms, swarm, produce surfactants molecules that have antimicrobial activity against selected pathogens. assess potential probiotic isolates, we tested resistance cells spores simulated gastric conditions, grow sporulate in anaerobic conditions presence toxin-encoding genes their genome.Spore-formers belonging bacterial been gut volunteers. These strains appear be well adapted intestinal environment propose them as for use oral vaccine vehicles.To our knowledge this is first detailed characterization spore-forming Bacilli GIT. Our data suggest do not transit, but rather specific habitat use.