Pharmacokinetics and bioavailability of spectinomycin after i.v., i.m., s.c. and oral administration in broiler chickens

• DOI: 10.1111/j.1365-2885.2007.00825.x
• Publication Date: 2007-03-06T18:08:20Z
• Authors: E. A. ABU‐BASHA; R. GEHRING; S. J. ALBWA'NEH
• Keywords: 0301 basic medicine; Spectinomycin; Injections, Subcutaneous; Administration, Oral; Biological Availability; Injections, Intramuscular; Anti-Bacterial Agents; 3. Good health; 03 medical and health sciences; Area Under Curve; Animals; Infusions, Intravenous; Chickens

A pharmacokinetic and bioavailability study of spectinomycin was conducted in healthy broiler chickens following administration a single (50 mg/kg bw) intravenous (i.v.), intramuscular (i.m.) subcutaneous (s.c.) dose oral doses 50 100 bw. Following i.v. administration, the elimination half‐life ( t 1/2 β ), mean residence time MRT volume distribution at steady‐state V d(ss) based on terminal phase d(z) ) total body clearance Cl B were 1.46 ± 1.10 h, 1.61 1.05 0.26 0.009 L/kg, 0.34 (0.30–0.38) L/kg 2.68 0.017 mL/min/kg respectively. After i.m. s.c. dosing, C max 152.76 1.08 99.77 1.04 μ g/mL, achieved 0.25 (0.25–0.50) (0.25–1.00) 1.65 1.07 2.03 1.06 h absolute F 136.1% 128.8% significant difference (5.13 0.10, 14.26 1.12 g/mL), (3.74 1.07, 8.93 1.13 h) / (22.69 0.018, 10.14 0.018 mL/min/kg) found between two bw respectively), but there no differences [2.00 (2.00–4.00), 2.00 (2.00–2.00) h] [6.95 (6.34–9.06), 7.98 (4.75–10.62) L/kg). The 11.8% 26.4% after