Comparison of hepatic oxidative DNA damage in patients with chronic hepatitis B and C

• DOI: 10.1111/j.1365-2893.2008.00972.x
• Publication Date: 2008-03-07T01:04:14Z
• Authors: N. Fujita; R. Sugimoto; N. Ma; H. Tanaka; M. Iwasa; Y. Kobayashi; S. Kawanishi; S. Watanabe; M. Kaito; Y. Takei
• Keywords: Hepatitis B

Summary. 8‐Hydroxydeoxyguanosine (8‐OHdG) is a promutagenic DNA lesion produced by hydroxyl radicals and recognized as useful marker in estimating damage induced oxidative stress. The aim of this study was to clarify the clinical significance hepatic 8‐OHdG levels patients with chronic viral hepatitis. Hepatic accumulation investigated hepatitis C (CH‐C) ( n = 77) B (CH‐B) 34) immunohistochemical staining liver biopsy samples. positive hepatocytes were significantly higher CH‐C compared CH‐B (median 55.0 vs 18.8 cells/10 5 μm 2 , P < 0.0001). number increased elevation serum aminotransferase levels, especially (8‐OHdG alanine (ALT)/aspartate aminotrasferase (AST) r 0.738/0.720 0.506/0.515 CH‐B). reactivity strongly correlated body iron storage markers ferritin, 0.615; total score, 0.520; hepcidin mRNA 0.571), although it related HBV‐DNA titers 0.540) age –0.559) CH‐B. These results indicate that common hepatitis, particular HCV‐infected patients, suggesting possible link between inflammation hepatocarcinogenesis. strong correlation overload suggests content one most likely mediators stress reduction may be beneficial reduce incidence cancer patients.