SERUM ANGIOTENSIN CONVERTING ENZYME ACTIVITY AND PLASMA RENIN ACTIVITY IN EXPERIMENTAL MODELS OF RATS

• DOI: 10.1111/j.1440-1681.1990.tb01338.x
• Publication Date: 2007-06-29T05:50:46Z
• Authors: María Elena Ibarr...; Cristino Cruz; Edilia Tapia; José Carlos Peña; José Pedraza‐Chav...
• Keywords: Male; Nephrotic Syndrome; Isoproterenol; Rats, Inbred Strains; Sodium, Dietary; Peptidyl-Dipeptidase A; Nephrectomy; Propranolol; Rats; 3. Good health; Disease Models, Animal; 03 medical and health sciences; Hypertension, Renovascular; 0302 clinical medicine; Renin; Animals; Kidney Diseases

ABSTRACT1. Serum angiotensin converting enzyme activity (ACEA) and plasma renin activity (PRA) were determined in rats under different experimental conditions such as: nephrotic syndrome (NS), bilateral nephrectomy (BN), renovascular hypertension (RH), dehydration (DEH), anaesthesia (AN), low sodium diet (LSD) and high sodium diet (HSD), and injection with propranolol (PRO) and isoprenaline (ISO).2. PRA increased in LSD, AN, NS, RH, DEH and IPT groups, and decreased in HSD, BN, and PRO groups. Serum ACEA did not change in RH, HSD, IPT, DEH, AN, and PRO groups, increased in NS group, and decreased in LSD and BN groups.3. Serum ACEA changed in the opposite direction to PRA only in the LSD group. This finding suggests that ACE may limit the full expression of the reninangiotensin system in the LSD group, but not in the other groups.