Factors affecting the mortality of pediatric fulminant hepatic failure in relation to hepatitis B virus infection

• DOI: 10.1111/j.1440-1746.2005.03923.x
• Publication Date: 2005-07-01T17:36:07Z
• Authors: PEI‐CHUN CHAN; HUEY‐LING CHEN; MAN‐SHAN KONG; FU‐CHEN HUANG; HUNG‐CHANG LEE; CHIEH‐CHUNG LIN; CHING‐CHUAN LIU; I‐HSIEN LEE; TZEE‐CHUNG WU; SHU‐FEN WU; YEN‐HSUAN NI; HONG‐YUAN HSU; MEI‐HWEI CHANG
• Keywords: Fulminant hepatic failure; Hepatitis B; Prothrombin time; Fulminant hepatitis

Abstract Aim: To investigate the factors affecting outcome of fulminant hepatic failure (FHF) in children relation to hepatitis B virus (HBV) infection. Methods: Retrospective review a total 94 cases (61 males and 33 females, aged from 1 month 15 years) recruited nine tertiary referral centers Taiwan 1985 1999. Results: The overall mortality rate was 75%. Patients group were an older age, had higher peak bilirubin levels, longer prothrombin time, lower percentage HBV positivity ( P < 0.001, = 0.003, 0.0027 0.042, respectively). Mortality 65% positive n 42) 83% negative 52) 0.05). In group, time noted be single factor 0.036). age value serum suggestive poor survival 0.001 0.006, Multivariate analysis revealed that HBV‐negative group. three consecutive periods without liver transplantation (1985–1989, 1990–1994, 1995–1999) decreased gradually (91, 67 38%, respectively, with 0.027). This change not observed cases. Conclusions: Hepatitis FHF than FHF, each having different mortality.