Changes in thyroid function after bone marrow transplant in young patients

• DOI: 10.1111/j.1442-200x.2004.01894.x
• Publication Date: 2004-05-18T14:03:57Z
• Authors: Masae Matsumoto; Hiroyuki Ishiguro; Yuichirou Tomita; Hiroyasu Inoue; Yukiharu Yasuda; Takashi Shimizu; Tsuyoshi Shinagawa; Kinya Hattori; Hiromasa Yabe; Chidori Kubota; Miharu Yabe; Shunichi Kato; Osamu Shinohara
• Keywords: Basal (medicine); Euthyroid sick syndrome; Total body irradiation

Abstract Background : Changes in thyroid function among young patients who received bone marrow transplantation (BMT) were evaluated. Methods The study included 91 (50 males) underwent BMT from 1985 to 1995 at the age of 0.6−21 years. Sixty had neoplastic disease such as leukemia or lymphoma, and remainder non‐neoplastic diseases. Preconditioning regimen for 12 Gy fractionated‐total body irradiation (TBI) with 3−8 remaining patients, addition chemotherapy. Evaluation was performed by serial assessment basal serum FT4, FT3, TSH concentrations well TRH test. Results No patient overt hypothyroidism elevated (>10 mU/L). However, 6 (7%) experienced exaggerated peak response stimulation several years after BMT. In 33 whose status evaluated before, within 3 months, 1 year BMT, FT3 significantly decreased immediately (<3 months) normalized year. FT4 did not change significantly. One developed primary another follicular adenoma 5 respectively. Conclusion Short‐term changes can indicate euthyroid sick syndrome rather than tertiary hypothyroidism. It must be noted that may occur hence long‐term follow‐up is warranted.