ACUTE LYMPHOBLASTIC LEUKEMIA IN CHINESE ADULTS IN HONG KONG
Adult
Male
China
Adolescent
Prednisolone
Middle Aged
Precursor Cell Lymphoblastic Leukemia-Lymphoma
3. Good health
03 medical and health sciences
0302 clinical medicine
Doxorubicin
Risk Factors
Vincristine
Antineoplastic Combined Chemotherapy Protocols
Asparaginase
Hong Kong
Humans
Female
Child
Aged
DOI:
10.1111/j.1445-5994.1989.tb01672.x
Publication Date:
2008-03-25T10:57:56Z
AUTHORS (6)
ABSTRACT
Abstract:Forty‐four previously untreated Chinese adult patients with acute lymphoblastic leukemia (ALL) were treated with vincristine, adriamycin and prednisone with or without L‐asparaginase. The clinical features and prognostic factors were similar to those reported in Caucasian series. Overall complete remission (CR) rate was 52%. Duration of first remission and overall median survival were nine and 12 months respectively. The addition of L‐asparaginase did not improve CR rate or duration of remission and was associated with clotting dysfunction and other adverse reactions. Factors associated with a higher CR rate include age < 40 years, blast count < 10 times 109/1 and CALLA+phenotype at presentation. Sex, platelet count and FAB morphology did not affect CR rate.Bone marrow relapse occurred in 11 patients and was associated with short survival after relapse (median two months; mean two months; range 0.5–7 months). Central nervous system relapse occurred in four patients and was compatible with relatively long survival after relapse (median 13 months; mean 12 months; range 6–12 + months).The poor CR rate and short median survival in this study could not be adequately explained by an increase in risk factors and is likely to be due to what is currently regarded as suboptimal chemotherapy. (Aust NZ J Med 1989; 19: 37–43.)
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