The prognostic value of peritumoral regulatory T cells and its correlation with intratumoral cyclooxygenase‐2 expression in clear cell renal cell carcinoma

• DOI: 10.1111/j.1464-410x.2008.08151.x
• Publication Date: 2008-11-19T16:51:04Z
• Authors: Jin F. Li; Yi W. Chu; Guo M. Wang; Tong Y. Zhu; Rui M. Rong; Jun Hou; Ming Xu
• Keywords: Tissue microarray; Immunostaining

To investigate the prognostic value of regulatory T cells (Tregs) and its correlation with cyclooxygenase-2 (COX-2) expression in clear cell renal carcinoma (RCC).CD4+, Foxp3+ tumour-infiltrating lymphocytes tumour COX-2 were assessed by immunohistochemistry tissue microarrays containing RCC from 125 patients. Prognostic effects low high evaluated Cox regression Kaplan-Meier analysis using median values as thresholds. The Tregs compared clinicopathological variables. In addition, was also analysed.Peritumoral positively correlated intratumoral (Spearman rank 0.336, P < 0.001). Peritumoral associated TNM stage (P = 0.001) size 0.002), while 0.018) grade 0.013). Using multivariate analysis, increased peritumoral Tregs, higher (III + IV), larger (> or =7 cm) nuclear IV) independent predictors for significantly shorter overall survival disease-free survival.Increased are worse prognosis RCC. may be underlying reason aberrant gathering Tregs. These results suggest that clinical application inhibitors benefit those patients immunostaining reducing transformation