Screening for pre‐diabetes to predict future diabetes using various cut‐off points for HbA1c and impaired fasting glucose: the Toranomon Hospital Health Management Center Study 4 (TOPICS 4)

• DOI: 10.1111/j.1464-5491.2012.03686.x
• Publication Date: 2012-04-17T16:31:29Z
• Authors: Y. Heianza; Y. Arase; K. Fujihara; H. Tsuji; K. Saito; S. D. Hsieh; S. Kodama; H. Shimano; N. Yamada; S. Hara; H. Sone
• Keywords: Impaired fasting glucose

Diabet. Med. 29, e279‐e285 (2012) Abstract Aim To evaluate various screening criteria for pre‐diabetes to identify which combination of impaired fasting glucose and elevated HbA 1c values performs most effectively in predicting future diabetes a large cohort Japanese individuals. Methods The study included 4670 men 1571 women without (diabetes: plasma ≥ 7.0 mmol/l, 48 mmol/mol (≥ 6.5%), or self‐reported clinician‐diagnosed diabetes). Pre‐diabetes was diagnosed by (fasting 5.6–6.9 mmol/l 6.1–6.9 mmol/l) [39–46 (5.7–6.4%) 42–46 (6.0–6.4%)]. Results During 5‐year follow‐up, 338 incident cases occurred. 39–46 yielded the highest sensitivity (86%) generated population‐attributable per cent risk (78%) development diabetes. Among individuals classified as having any four combined criteria, 20.5–32.0% reverted normoglycaemic state neither nor at last follow‐up examination. At 5.6 years after baseline examination, however, pre‐diabetic who fulfilled both (6.0–6.4%) had 100% cumulative developing Conclusions would have best performance reducing likelihood missing Identifying strictly fulfil predict definite progression