Fatigue among HIV‐infected patients in the era of highly active antiretroviral therapy

• DOI: 10.1111/j.1468-1293.2005.00319.x
• Publication Date: 2005-09-07T13:32:39Z
• Authors: M Henderson; F Safa; P Easterbrook; M Hotopf
• Keywords: Depression; General Health Questionnaire

To describe the prevalence of operationally defined fatigue in an ethnically diverse HIV-infected population south London, and to examine association with demographic characteristics, stage disease, antiretroviral therapy psychological factors.A descriptive comparative cross-sectional study patients attending a London HIV clinic over 5-month period 2002 was performed. Demographic clinical data were obtained from local database. Participants completed four self-administered questionnaires-the Chalder Fatigue Scale (CFS), measure physical mental fatigue; General Health Questionnaire (GHQ-12) detect anxiety depression; Medical Outcomes Study 36-Item Short-Form Survey (SF-36) functional status, Illness Perception (IPQ). 'cases' as those scoring at least 4 on CFS. Multivariate logistic regression used identify factors associated presence fatigue.Two hundred five approached 148 (72%) agreed participate. Overall, 65% fatigued. Significant distress GHQ-12, impairment SF-36 higher CD4 count all independently fatigue. There no use or characteristics.The is most strongly not more advanced disease highly active therapy. This highlights importance investigation management underlying depression presenting