EFNS Guidelines on diagnosis and treatment of brain metastases: report of an EFNS Task Force

• DOI: 10.1111/j.1468-1331.2006.01506.x
• Publication Date: 2006-06-23T13:45:45Z
• Authors: R. Soffietti; P. Cornu; J. Y. Delattre; R. Grant; F. Graus; W. Grisold; J. Heimans; J. Hildebrand; P. Hoskin; M. Kalljo; P. Krauseneck; C. Marosi; T. Siegal; C. Vecht
• Keywords: Task force

The objectives have been to establish evidence-based guidelines and identify controversies regarding the management of patients with brain metastases. collection scientific data was obtained by consulting Cochrane Library, bibliographic databases, overview papers previous from societies organizations. A tissue diagnosis is necessary when primary tumor unknown or aspect on computed tomography/magnetic resonance imaging atypical. Dexamethasone corticosteroid choice for cerebral edema. Anticonvulsants should not be prescribed prophylactically. Surgery considered in up three metastases, being effective prolonging survival systemic disease absent/controlled performance status high. Stereotactic radiosurgery metastases 3-3.5 cm maximum diameter. Whole-brain radiotherapy (WBRT) after surgery debated: case cancer Karnofsky Performance score 70 more, one can either withhold initial WBRT deliver early conventional fractionation avoid late neurotoxicity. alone treatment single multiple amenable radiosurgery. Chemotherapy may chemosensitive tumors.