Disease protection and interleukin‐10 induction by endogenous interferon‐β in multiple sclerosis?

• DOI: 10.1111/j.1468-1331.2010.03116.x
• Publication Date: 2010-06-15T04:05:36Z
• Authors: D. Hesse; M. Krakauer; H. Lund; H. B. Søndergaard; S. J. W. Limborg; P. Soelberg Sørensen; F. Sellebjerg
• Keywords: Ex vivo

An immune activation response resembling virus or type I interferon responses has been observed in untreated multiple sclerosis (MS), but its pathogenic significance is uncertain. We studied the relationship between a interferon-like patients with MS and disease activity.Gene expression was analyzed by real-time reverse transcriptase polymerase chain reaction (PCR) whole blood samples microarray analysis of mononuclear cells from MS, treated IFN-β, anti-IFN-β neutralizing antibodies (NAb). Disease activity assessed gadolinium-enhanced magnetic resonance imaging.Eight 36 had spontaneously increased IFN-induced gene MX1. Microarray demonstrated that spontaneous MX1 also other genes induced regular IFN-β treatment MS. correlated FOXP3 IL10 expression, negatively on imaging. Further, vivo lower NAb-positive than healthy controls. Finally, ex IL10, this blocked addition serum MS.Our findings suggest endogenous may induce immunoregulatory might be associated dampening inflammatory activity.