Epithelial Ca2+ entry channels: transcellular Ca2+ transport and beyond

• DOI: 10.1111/j.1469-7793.2003.00729.x
• Publication Date: 2004-07-16T07:56:59Z
• Authors: Ji-Bin Peng; Edward M. Brown; Matthias A. Hediger
• Keywords: Transcellular; Paracellular transport

The recently discovered apical calcium channels CaT1 (TRPV6) and ECaC (TRPV5) belong to a family of six members called the ‘TRPV family’. Unlike other four which are nonselective cation functioning as heat or osmolarity sensors in body, remarkably calcium-selective serve entry mechanisms absorptive secretory tissues. is highly expressed proximal intestine, placenta exocrine tissues, whereas expression most prominent distal convoluted connecting tubules kidney. intestine responsive 1,25-dihydroxyvitamin D3 shows both fast slow calcium-dependent feedback inhibition prevent overload. In contrast, only inactivation kinetics appears be mostly regulated by load Outside calcium-transporting epithelia, tissues such pancreas, prostate salivary gland. these it probably mediates re-uptake following its release vesicles. also contributes store-operated Jurkat T-lymphocytes cancer LNCaP cells, possibly conjunction with cellular components link activity filling state stores. Finally, upregulated cancers epithelial origin, highlighting potential target for therapy.