Human chorionic gonadotrophin inhibition of pregnant human myometrial contractility

• DOI: 10.1111/j.1471-0528.2001.00178.x
• Publication Date: 2003-12-22T17:21:28Z
• Authors: Michael M. Slattery; Cara Brennan; Michael J. O'Leary; John J. Morrison
• Keywords: Myometrium; Contractility; Human chorionic gonadotropin; Tocolytic

Objective To evaluate the effect of human chorionic gonadotrophin (hCG) on pregnant myometrial contractility in vitro and to determine whether hCG‐elicited was oestrogen dependant. Methods Isometric tension recording performed under physiological conditions isolated strips from biopsies obtained at elective caesarean section. The cumulative additions hCG (0.001, 0.01, 0.1, 1.0 10 iu/mL) evaluated. Secondarily, contractile activity myometrium following exposure investigated tissue pre‐treated with beta‐oestradiol. Results exerted a statistically significant relaxant tissue. increased increasing concentrations 8.96% (SEM 2.06) (0.001 iu/mL hCG; P <0.01) net total 58.50% 3.74) (10 <0.01). also time‐dependant, magnitude throughout duration experiments. Beta‐oestradiol did not significantly affect response hCG. Conclusions These results clearly demonstrate that exerts concentration‐dependant rate pregnancy. findings outline an inhibitory role raise possibility its potential use as tocolytic.