BIOCHEMICAL CORRELATES OF TRANSMISSION MEDIATED BY GLUTAMATE AND ASPARTATE

• DOI: 10.1111/j.1471-4159.1978.tb12442.x
• Publication Date: 2006-12-13T13:02:15Z
• Authors: J. V. Nadler; W. F. White; K. W. Vaca; B. W. Perry; C. W. Cotman
• Keywords: Mossy fiber (hippocampus)

Abstract— Glutamate and aspartate probably serve as transmitters of hippocampal perforant path commissural afferents, respectively. We therefore used slices regions to evaluate certain biochemical properties markers for sites transmission mediated by these amino acids. In studies content accumulation glutamate were compared with their Ca 2+ ‐dependent effluxes. Hippocampal varied little in contents aspartate, but regio superior dentate gyrus accumulated released more each than inferior. A commissurotomy or bilateral entorhinal lesion altered efflux the same direction, did not affect any region. Elimination mossy fibers reduced from gyrus, inferior, where most fiber synapses are located. The appeared relatively deficient both strains tested, only Purdue‐Wistar rats they enriched glutamate. Removal input fascia dentata significantly change activity enzymes actively involved synthesis. These results suggest that high affinity transport can be employed localize afferents which use acids transmitters, although it is so reliable selective a marker efflux. Enrichment either synthesize them marker. Neither acid likely transmitter fibers.