ATROPINE ENHANCES NEUROMUSCULAR TRANSMISSION IN HUMANS

• DOI: 10.1111/j.1472-8206.1987.tb00545.x
• Publication Date: 2009-08-26T18:14:08Z
• Authors: F.A. WALI; E.G. BRADSHAW; A.H. SUER; C.H. DARK
• Keywords: Neuromuscular transmission

Summary— The effect of atropine (1–10 μ‐kg‐ 1 ) on neuromuscular transmission in humans was studied by analysing its effects the amplitude indirectly‐elicited twitch (0.2 Hz) and tetanic (50 100 Hz for s duration) contractions. Six patients, free from any disorders, undergoing orthopaedic surgery, were included present study. patients received either no premedication or oral benzodiazepine, temazepam, 30 mg 1–2 h pre‐operatively. Anaesthesia induced with propofol (1–2 mg‐kg‐ , i.v., over 20 s). breathed less than 30% oxygen nitrous oxide, halothane (1%) enflurane (1–2%). Incremental doses fentanyl (50–100 μ) given to provide additional analgesia. ulnar nerve stimulated, supramaximally, at wrist, control mechanical responses adductor pollicis muscle, stimulation 50 duration, recorded. Theses repeated 2, 5 10 min intervals, after injection ). At same time, heart rate blood pressures (systolic diastolic) results showed that enhanced contractions, elicited 27 ± 1.2% atropine, 220 13 g tension), 43 7% (100 333 26 tension) intervals (mean S.E., n = 6). also increased, 24 2.5% (heart 110±3.5 beats/min), 16±1.0% 138±2.2 mm Hg), 13±1.1% (diastolic 76±1.5 this precluded use higher ( e.g. 1.2 mg, i.e. our mechanism action junction, are discussed reference animal work, which has been shown enhance and/or transmitter (ACh) release, possibly acting muscarinic presynaptic inhibitory receptors, involved feedback release.