THE OUTPUT PER STIMULUS OF ACETYLCHOLINE FROM CEREBRAL CORTICAL SLICES IN THE PRESENCE OR ABSENCE OF CHOLINESTERASE INHIBITION

• DOI: 10.1111/j.1476-5381.1974.tb09718.x
• Publication Date: 2012-07-19T17:52:50Z
• Authors: P.S. BOURDOIS; J.F. MITCHELL; G.T. SOMOGYI; J.C. SZERB
• Keywords: Physostigmine; Stimulus (psychology); Cholinesterase; Choline

1 The release of endogenous acetylcholine (ACh) from cerebral cortical slices stimulated at 0.25, 1, 4, 16 and 64 Hz was measured in the presence either physostigmine or atropine.2 Atropine potentiated evoked ACh especially low frequencies resulting an output per stimulus which sharply declined with increasing frequency stimulation, while absence atropine fairly constant.3 [(3)H]-ACh following incubation [(3)H]-choline, as estimated by means rate constants total radioactivity, showed a dependence similar to when two were tested under identical conditions.4 In anticholinesterase dependent on stimulation way that atropine.5 Results suggest physiological conditions, i.e. anti-cholinesterase, decreases this decrease is due lag mobilization stored rather than synthesis new ACh.