How Is the Liver Primed or Sensitized for Alcoholic Liver Disease?

• DOI: 10.1111/j.1530-0277.2001.tb02393.x
• Publication Date: 2006-04-11T10:13:21Z
• Authors: Hidekazu Tsukamoto; Yoshiyuki Takei; Craig J. McClain; S. Joshi‐Barve; D. Hill; J. Schmidt; I. Deaciuc; S. Barve; Anna Colell; Carmen Garcia‐Ruiz; Neil Kaplowitz; Jose C. Fernandez...; Hirokazu Yokoyama; Yukishige Okamura; Yuji Nakamura; Hiromasa Ishii; Rajendar K. Chawla; S. Barve; S. Joshi‐Barve; W. Watson; W. Nelson; Min Lin; Mitsuru Ohata; Kenta Motomura; N. Enomoto; K. Ikejima; T. Kitamura; H. Oide; M. Hirose; B. U. Bradford; C. A. Rivera; H. Kono; S. Peter; S. Yamashina; A. Konno; M. Ishikawa; H. Shimizu; N. Sato; R. Thurman
• Keywords: 0301 basic medicine; S-Adenosylmethionine; 0303 health sciences; Kupffer Cells; Tumor Necrosis Factor-alpha; Iron; Gene Expression; Mitochondria, Liver; Tretinoin; 3. Good health; Endotoxins; 03 medical and health sciences; Liver; Superoxides; Hepatocytes; Animals; Humans; Peroxisome Proliferators; Bezafibrate; Liver Diseases, Alcoholic; Hypolipidemic Agents

This article represents the proceedings of a symposium at 2000 ISBRA Meeting in Yokohama, Japan. The chairs were Hidekazu Tsukamoto and Yoshiyuki Takei. presentations (1) Tribute to Professor Rajendar K. Chawla, by Craig J. McClain; (2) Dysregulated TNF signaling alcoholic liver disease, McClain, S. Joshi‐Barve, D. Hill, J Schmidt, I. Deaciuc, Barve; (3) role mitochondria ethanol‐mediated sensitization liver, Anna Colell, Carmen Garcia‐Ruiz, Neil Kaplowitz, Jose C. Fernandez‐Checa; (4) A peroxisome proliferator (bezafibrate) can prevent superoxide anion release into hepatic sinusoid after acute ethanol administration, Hirokazu Yokoyama, Yukishige Okamura, Yuji Nakamura, Hiromasa Ishii; (5) S‐adenosylmethionine affects tumor necrosis factor‐α gene expression macrophages, Barve, W. Watson, Nelson, (6) Iron, retinoic acid macrophage TNFα ALD, Tsukamoto, Min Lin, Mitsuru Ohata, Kenta Motomura; (7) Role Kupffer cells gut‐derived endotoxin injury, N. Enomoto, Ikejima, T. Kitamura, H. Oide, Y. Takei, M. Hirose, B. U. Bradford, A. Rivera, Kono, Peter, Yamashina, Konno, Ishikawa, Shimizu, Sato, R. Thurman.