Pharmacokinetics of orally administered omeprazole in children

• DOI: 10.1111/j.1572-0241.2000.03256.x
• Publication Date: 2004-03-29T15:39:26Z
• Authors: Tommy Andersson; Eric Hassall; Per Lundborg; Ross Shepherd; Michael Radke; Margaret Marcon; Agneta Dalvagag; Steve Martin; Rolf Behrens; Sibylle Koletzko; Michael Becker; Eric Drouin; Gunnar Gothberg
• Keywords: Tolerability

The aim of this study was to examine the pharmacokinetics orally administered omeprazole in children.Plasma concentrations were measured at steady state over a 6-h period after administration drug. Patients subset those multicenter determine dose, safety, efficacy, and tolerability treatment erosive reflux esophagitis children. Children 1-16 yr age, with pathological acid on 24 h-intraesophageal pH study. "healing dose" that which subsequent intraesophageal normalized. remained dose for 3 months, during measured.A total 57 children enrolled overall healing phase Pharmacokinetic optional subjects performed 25 enrolled. doses required substantially higher per kilogram body weight than adults. Values pharmacokinetic parameters generally within ranges previously reported However, plasma levels, area under concentration versus time curve (AUC), half-life (t(1/2)), maximal (Cmax), lower younger age group, when AUC Cmax normalized 1 mg/kg. Furthermore, group as whole, these values showed gradation from lowest 1-6 older groups.The trend toward metabolic capacity decreasing being highest age. This may explain need basis, not only compared adults but, many cases, particularly