Treatment of Idiopathic Gastroparesis With Injection of Botulinum Toxin Into The Pyloric Sphincter Muscle

• DOI: 10.1111/j.1572-0241.2002.05823.x
• Publication Date: 2004-03-26T14:15:01Z
• Authors: Larry S Miller; Gregory A Szych; Steven B Kantor; Matthew Q Bromer; Linda C Knight; Alan H Maurer; Robert S Fisher; Henry P Parkman
• Keywords: Gastroparesis; Prokinetic agent

We aimed to determine if botulinum toxin injection into the pyloric sphincter improves gastric emptying and reduces symptoms in patients with idiopathic gastroparesis.Patients gastroparesis not responding prokinetic therapy underwent (80-100 U, 20 U/ml) sphincter. Gastric scintigraphy was performed before 4 wk after treatment. Total symptom scores were obtained from sum of eight upper GI graded on a scale 0 (none) (extreme).Ten entered study. The mean percentage solid retention at h improved 27+/-6% (normal < 10%) pylorus 14+/-4% (p = 0.038) score decreased 15.3+/-1.7 baseline 9.0+/-1.9 0.006) wk, 38+/-9% decrease. Improvement tended correlate solids (r 0.565, p 0.086).This initial pilot study suggests that both symptoms.