Correlation of Serum Soluble TNF-alpha Receptors I and II Levels with Disease Activity in Patients with Ulcerative Colitis

• DOI: 10.1111/j.1572-0241.2004.30432.x
• Publication Date: 2004-08-11T07:48:22Z
• Authors: Hiroyuki Hanai; Fumitoshi Watanabe; Masami Yamada; Yoshihiko Sato; Ken Takeuchi; Takayuki Iida; Kotaro Tozawa; Tatsuo Tanaka; Yasuhiko Maruyama; Isao Matsushita; Yasushi Iwaoka; Abby Saniabadi
• Keywords: Adult; Male; 0303 health sciences; Adolescent; Neutrophils; Remission Induction; Middle Aged; Monocytes; Neutrophil Activation; Receptors, Tumor Necrosis Factor; 3. Good health; 03 medical and health sciences; Antigens, CD; Receptors, Tumor Necrosis Factor, Type I; Humans; Receptors, Tumor Necrosis Factor, Type II; Colitis, Ulcerative; Female; Leukapheresis

OBJECTIVES TNF-α has a major role in inflammatory bowel disease via two receptors, p55 (RI) and p75 (RII) expressed on many cell types, particular neutrophils monocytes (GM). Upon activation of these leukocytes, RI RII are shed into the medium can neutralize TNF. Accordingly, soluble (s-RI/RII) believed to have potent antiinflammatory actions. Further, active UC, GM elevated with behavior recently adsorptive apheresis (GMA) patients severe UC was associated dramatic efficacy. In this study, we investigated effects GMA serum s-RI/RII. METHODS Thirty-one clinical activity index (CAI) 11.1 were treated by using Adacolumn. column, leukocytes which bear FcγR complement receptors adhere column carriers (neutrophils, monocytes, small fraction lymphocytes). One session 60 min at 30 mL/min each patient could receive up 11 sessions over 8 wk. Serum s-RI/II measured blood inflow (peripheral blood, time 0 min) outflow min. RESULTS s-RI/RII showed strong correlation CAI, r = 0.849 (p < 0.001) 0.867 0.001), respectively greater than when remission or levels controls 0.001). higher compared 0.05) suggesting that RI/RII from carriers. Similarly significantly increased peripheral end 0. After sessions, CAI fell level 26 31 accompanied falls CONCLUSIONS The sources be activated further release released during should contribute efficacy procedure.