Distribution ofvacAgenotypes inHelicobacter pyloristrains isolated from Brazilian adult patients with gastritis, duodenal ulcer or gastric carcinoma

• DOI: 10.1111/j.1574-695x.2002.tb00588.x
• Publication Date: 2006-01-09T14:58:41Z
• Authors: Abdussalam A.R. A...; Paula P. Magalhães; Edilberto N. Mendes; Guilherme B. Coll...; Valquíria R. Gus...; Dulciene M.M. Que...; Ana Margarida M.F...; Gifone A. Rocha; Celso A. Oliveira
• Keywords: Spirillaceae; Gastric carcinoma; Helicobacter

This PCR-based analysis is the first molecular epidemiological study in Brazil testing Helicobacter pylori cagA and vacA distribution adults with gastric complaints, that includes a large number of carcinoma patients. Multiple-strain infection was identified 11/13.4% s1-m1 cagA+ genotypes were most common patients non-mixed infection. All s1 strains s1b, so subtyping not useful. s1b-m1 associated higher prevalence peptic ulcer than s2-m2 cagA− ones. In conclusion, genotyping may have clinical relevance Brazil.