A novel diffusible substance can overcome the apparent AbrB repression of the Bacillus subtilis fatR promoter

• DOI: 10.1111/j.1574-6968.2001.tb10674.x
• Publication Date: 2006-01-09T14:40:28Z
• Authors: Mattias C.U. Gust...; Claes Wachenfeldt
• Keywords: 0303 health sciences; Genetic Complementation Test; Biological Transport; Gene Expression Regulation, Bacterial; Mixed Function Oxygenases; 3. Good health; DNA-Binding Proteins; Diffusion; 03 medical and health sciences; Bacterial Proteins; Cytochrome P-450 Enzyme System; Mutation; Operon; Gene Silencing; Promoter Regions, Genetic; Oligopeptides; Gene Deletion; Bacillus subtilis; NADPH-Ferrihemoprotein Reductase; Transcription Factors

In this work we present evidence for a novel diffusible extracellular factor that modulates gene expression in Bacillus subtilis. The was found when studying the regulation of fatR-cyp102A3 operon. Spo0A(-) mutant operon almost abolished. defect could be overcome either by mutation abrB or substance excreted wild-type, and abrB-spo0A double strains.