Aminoguanidine renders inducible nitric oxide synthase knockout mice more susceptible toSalmonella typhimuriuminfection

• DOI: 10.1111/j.1574-6968.2002.tb10992.x
• Publication Date: 2006-01-09T14:27:30Z
• Authors: Xin Zhou; Douglas A. Potoka; Patricia Boyle; Evan P. Nadler; Kathleen McGinnis; Henri R. Ford
• Keywords: Salmonella infection; Knockout mouse

Aminoguanidine (AG), a nitric oxide synthase (NOS) inhibitor, has been widely used to study the role of inducible NOS (iNOS) in host defense against infections caused by various pathogens including Salmonella typhimurium. iNOS reported play an important S. typhimurium infection both vitro and vivo. In this report we show those AG treatment lead weight loss wild-type knockout mice, rendered them more susceptible infection. These results suggest that may have side effects other than inhibition iNOS, data obtained from studies using should be interpreted with caution.